I'm in the 3rd year of a 12-team 2 QB, 2 TE league where all TDs are six points. I have now finished in 3rd in both seasons and a points leader for both seasons until losing at the very end (prize $ for being #1 in points).
In the first year I drafted Aaron Rodgers and Russell Wilson in Rounds 1 & 2. I picked early in the 1st and was able to gobble up Rodgers. Both had great seasons.
Last year I was picking at the end of the round. I felt that taking a QB after all the top guys had gone was a waste of a 1st round pick and I held off (I also used the Draft Dominator last year for the first time). Later on I took a gamble on Andy Dalton and Tyrod Taylor was my top 2 (also snagged Jameis Winston). It paid off, but it easily could have backfired. I got pretty lucky. I'm a Bills fan so I was high on Tyrod but I don't think anybody saw Dalton coming.
The only advise I really have is that you need to evaluate the draft based on your draft position. If you're going early on, strong consideration should be made to select a QB with your 1st round pick. If not, you may want to consider someone else (I believe I took Gronk at the end of round 1 in year 2). I do my own statistical projections and use that for my draft rankings and I don't feel good about any of the QBs ranked 25th and lower. You don't HAVE to get a QB in the first round. Actually I think the guy that has won it 2 out of the 3 years went RB/WR in the first 2 rounds and went QBs after that.
Generally if I don't have a shot at the top 5 QBs, I'll go to another area and make up for the loss in points somewhere else. I'd link you to my league from last year but the Commish still hasn't started it up yet so I can't access it.
My memory is fuzzy I guess. I picked #4 and took AP. I now remember the strategy at #4. If Luck and Rodgers were gone, I'd go RB. Luckily they both went ahead of me (I didn't expect such down years).
Here is the link:
http://fantasy.nfl.com/league/1117640/history/2015/draftresults?draftResultsTab=round&draftResultsType=results
If you click on the drop down it will also show you previous years. Keep in mind our scoring system: 2QB/2RB/3WR/2TE/1K/2DEF/1IDP & all TDs are 6 points.
I have a problem with dropping players too early. It's something I'm consciously aware of, so when I try to be patient I get burnt (kept Lacy in another league all year). I drafted Dalton round 5, Bortles 7, Winston 9, Tyrod 16. The goal was to find one of them that performed well. All of them ended up doing so, although I cut Bortles and Winston after poor starts to the season. I really dug myself a hole for bye weeks and when Dalton got injured and it ultimately led to me being knocked out of the playoffs with McCarron as my starter and finished 3rd.
End of year rankings: Bortles 4th, Winston 15th, Tyrod 17th, Dalton 18th. The last 2 obviously lost games to injury. Tyrod pro-rated would have been 12th, and Dalton pro-rated would have been 8th. So I would have had the 4th, 8th, 12th, 15th ranked QBs in a 12-team start 2 QB league which would have really put other teams at a disadvantage had I remained patient and they all stayed healthy.
I guess the point I'm making is that the philosophy worked out well of waiting until round 5 or so to go with the first QB and then take what the draft gives you. I did use draft dominator last year and that guided me pretty well. There were times when I trusted the program instead of doing what I would have otherwise done on my own. I listed to the program in terms of selecting a position and went with the guy I liked. The year before I didn't use the dominator and finished 3rd as well.
I still like this philosophy. Wait on a mid-range QB. Every year there are some guys who outperform their ADP, it's just typical. If you bust on a QB in the mid-rounds it hurts a lot less than taking Rodgers or Luck in the top 3 like happened with 2 of these guys. I also like the idea of drafting several QBs as it gives you options if something happens and always keeps your competition weaker as they'll have a weak 2nd QB and/or no backup QB options.
Another thought in these types of leagues is to target your 2 QBs with later bye weeks. Someone is bound to be injured/benched during the year which opens up WW possibilities for your backup. You could elect to not even draft a 3rd QB and roll with this method. Rivers, Carr, Tyrod, Osweiler, Ryan, Dalton etc. Guys with bye weeks 8,9,10 and later on gives you several weeks to come up with a backup option. Someone could be foolish like me and drop someone because they have no patience which would be an ideal WW pickup.