Just my opinion, but no way do I start Hoyer over Brees. I just think that Brees has a much higher floor (this week, and in general). It's not that unlikely that Jacksonville actually plays well enough to beat CLE, first of all. If that happens, it could be 13-10, or 31-28. Either way, there's a good chance CLE will have more success running than they will throwing.
Same thing could happen in the DET-NOS game, I suppose (could be high- or low-scoring), but I don't think the Saints will have a ton of luck running against the Lions. Brees will have to throw, and without Graham, I think he'll be looking to Cooks, Colston, and Thomas often. I think all three of those guys will see 8-10 targets, and with at least 5-6 catches.
I could understand benching Brees for another solid QB (Cutler, Wilson, or maybe even Romo/Flacco), but as good as Hoyer has played, he's not in that category. That doesn't mean Hoyer won't outscore Brees this week. I just think Brees is the much safer bet. I made the mistake of benching Brady a couple of weeks ago for Stanton (when ARI was playing DEN). Brady was sucking (and dealing with a supposed injury), and I figured the Cardinals would have to play from behind (and throw) against the Broncos. Stanton didn't even last a half. Obviously, the same thing could have happened to Brady, or any QB, for that matter. But, the lesson I learned (or was reminded of, anyway) is that it's silly to overthink things sometimes, and I should have stuck with the mantra of "always start your studs."
I think that applies in this case, unless (like I said), you have another similar option. Hoyer isn't a similar option. He's yet to exceed 300 yards this year, and has thrown for more than one score just once. He's also not a threat to run (he's rushed for less than 10 yards all year). Meanwhile, Brees has failed to throw for multiple scores just once, and is averaging well over 300 yards passing per game. In other words, his average passing game (in terms of yards) is 30+ yards higher than Hoyer's BEST game. And, Brees' worst game, in terms of scores, is just slightly worse than Hoyer's average game.